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KMID : 0043320180410070737
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Archives of Pharmacal Research
2018 Volume.41 No. 7 p.737 ~ p.742
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Two new naphthalenic lactone glycosides from Cassia obtusifolia L. seeds
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Shrestha Srijan
Paudel Pradeep
Seong Su-Hui
Min Byung-Sun
Seo Eun-Kyoung
Jung Hyun-Ah
Choi Jae-Sue
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Abstract
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Two new naphthalenic lactone glycosides, (3S)-9,10-dihydroxy-7-methoxy-3-methyl-1-oxo-3,4-dihydro-1H-benzo[g]isochromene-3-carboxylic acid 9-O-β-d-glucopyranoside (1) and (3R)-cassialactone 9-O-β-d-glucopyranoside (2) were isolated from seeds of Cassia obtusifolia Linn., along with five known compounds: (3R)-cassialactone 9-O-β-d-gentiobioside (3), emodin 1-O-β-gentiobioside (4), 1-hydroxyl-2-acetyl-3,8-dimethoxy-naphthalene 6-O-β-d-apiofuranosyl-(1?→?2)-β-d-glucopyranoside (5), rubrofusarin 6-O-β-d-gentiobioside (6), rubrofusarin 6-O-β-d-triglucoside (7). Structures of 1 and 2 were elucidated by NMR and HR-ESI-MS spectroscopic analysis. Their stereochemistry was determined by CD experiment. All compounds were tested for their ability to inhibit the formation of advanced glycation end-products in vitro. Compounds 1, 2, 3, 5, and 6 showed significant in vitro inhibitory activities (IC50 values of 11.63, 23.40, 7.32, 89.03, and 38.89 μM, respectively).
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KEYWORD
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Cassia obtusifolia, Naphthalenic lactone glycosides, Advanced glycation end-products
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